Charles Biddle, the son of William Biddle and Mary Scull, was born into an old and wealthy Quaker family in New Jersey. Charles and his wife, Hannah Shepard of Beaufort, North Carolina, became the parents of Nicholas Biddle of banking and political fame.
Biddle served as an ex officio trustee of the University of the State of Pennsylvania (now the University of Pennsylvania) during his term as vice president of Pennsylvania’s Supreme Executive Council (the equivalent of lieutenant-governor).